Association between APOE gene and m

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Original Article Association between APOE gene and myocardial bridge in Chinese Han population: a case-control study
Jie Liu1, Hong-Xin Zhang2, Zhi-Jun Wu3, Jing Tang3, Xiu-Xiu Su3, Yan-Jia Chen3, Wei Jin3
1Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University
School of Medicine, Shanghai, China; 2Research Center for Experimental Medicine, State Key Laboratory of
Medical Genomics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;
3Department of Cardiology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai,
China
Received January 3, 2016; Accepted March 17, 2016; Epub April 1, 2016; Published April 15, 2016
Abstract: Studies found that APOE gene play an important role in the development of cardiovascular disease. To
investigate the genetic association between myocardial bridge (MB) and APOE gene, we conducted this case-control
study and genotyped 5 SNPs using ligase detection reaction in 419 patients and 504 controls. The results indicated
that, in total group, rs405509, rs769450, rs439401, rs7259004 and rs2075650 showed no significant association
with myocardial bridge. The p value are all more than 0.05 and the OR [95% CI] value all included “1”, both in
the allele analysis and in the genotype analysis. In both the female-subgroup and male-subgroup, when subdivided
by genders, these 5 SNPs showed no significant association with myocardial bridge. Linkage disequilibrium (expressed
in D’ and r2) for APOE in the Chinese cases and controls are demonstrated and according to the results of
Linkage disequilibrium, the haplotype of the first 3 SNPs (rs405509, rs769450, rs439401) in the first block were
analyzed. This is the first case-control association study on APOE gene and myocardial bridge. Considering the size
of our sample sets (power > 90%), our results suggest that the APOE gene may not play a major role in myocardial
bridge in the Chinese Han population.

Keywords: Myocardial bridge, APOE, association study, SNP


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